Vladimir Semenovich Akatov

Furinopodobnye Proteinazy I Metalloproteinaza Mt1-mmp: Rol' V Kantserogeneze I Virusnykh Zabolevaniyakh Vladimir Semenovich Akatov Russian edition

Proteoliz i obespechivayushchie ego proteinazy reguliruyut vazhneyshie etapy zhiznedeyatel'nosti i metabolizma vsekh zhivykh organizmov, vklyuchaya virusy, bakterii i eukarioticheskie kletki. Krome togo, proteoliz yavlyaetsya neot"emlemoy chast'yu patologicheskikh protsessov, vklyuchaya infektsionnye i zlokachestvennye zabolevaniya. Proteoliticheskiy mekhanizm lezhit v osnove retseptor-indutsirovannogo apoptoza opukholevykh kletok, initsiirovannogo tsitokinom TRAIL/Apo2L. Issledovaniya v etom napravlenii predstavlyayut kak nauchnyy, tak i prakticheskiy interes. V rabote predstavleny novye eksperimental'nye dannye o roli matriksnoy metalloproteinazy MT1-MMR v zlokachestvennoy transformatsii kletok. V chastnosti pokazano, chto v rezul'tate MT1-MMP zavisimogo gidroliza tsentrosomal'nykh belkov v kletke voznikayut narusheniya mitoticheskogo veretena deleniya, chto privodit k geneticheskoy nestabil'nosti, khromosomnym aberratsiyam i aneuploidii. Opisana rol' furinovykh proteiniz v proniknovenii toksina sibirskoy yazvy v kletki zhivotnykh, a takzhe rol' furinopodobnoy proteinazy NS3 virusa Likhoradki Zapadnogo Nila v razvitii etogo virusnogo zabolevaniya. Monografiya predstavlyaet interes dlya spetsialistov v oblasti biomeditsiny, dlya studentov i aspirantov.