Yuriy Sheremet'ev

Mekhanizmy La3+- Indutsiruemykh Agregatsii I Sliyaniya Eritrotsitov: Agregatsiya I Sliyanie Eritrotsitov Yuriy Sheremet'ev Russian edition

Rabota posvyashchena izucheniyu mekhanizmov lantan - indutsiruemykh agregatsii i sliyaniya eritrotsitov. Ustanovleno, chto iony lantana indutsiruyut agregatsiyu eritrotsitov cheloveka, kur, krysy i byka. Pri kontsentratsiyakh ionov lantana, indutsiruemykh agregatsiyu eritrotsitov, proiskhodit transformatsiya ikh formy: eritrotsity iz diskotsitov prevrashchayutsya v stomatotsity. Provedennye issledovaniya pozvolyayut ponyat' mekhanizm agregiruyushchego deystviya ionov lantana na eritrotsity, nachal'nym etapom kotorogo yavlyaetsya vkhod lantana v kletki i vzaimodeystvie ego s belkami tsitoskeleta, a konechnym etapom obrazovanie na poverkhnosti membran diskretnykh oblastey, obladayushchikh sil'nym elektricheskim zaryadom. Elektrostaticheskoe vzaimodeystvie trekhvalentnogo kationa lantana s s uchastkami membran sosednikh kletok, obladayushchikh sil'nym otritsatel'nym zaryadom, privodit k agregatsii eritrotsitov. Pokazano,chto iony lantana indutsiruyut massovoe polnoe sliyanie eritrotsitov, imeyushchikh izmenennyy uroven' ATF. V rezul'tate sliyaniya obrazuyutsya gigantskie sfericheskie kletki, v kotorye vveden mikroelektrod i izmeren transmembrannyy potentsial pokoya. V protsesse sliyaniya eritrotsitov proiskhodit izmenenie belkovogo sostava tsitoskeleta i vnutrimembrannykh chastits kletok.